Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A(2A) and Dual A(1)/A(2A) Receptor Affinity

Chronic inflammation plays an important role in the development of neurodegenerative diseases, such as Parkinson’s disease (PD). In the present study, we synthesized 25 novel xanthine derivatives with variable substituents at the N1-, N3- and C8-position as adenosine receptor antagonists with potent...

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Detalles Bibliográficos
Autores principales: Załuski, Michał, Łażewska, Dorota, Jaśko, Piotr, Honkisz-Orzechowska, Ewelina, Kuder, Kamil J., Brockmann, Andreas, Latacz, Gniewomir, Zygmunt, Małgorzata, Kaleta, Maria, Greser, Beril Anita, Olejarz-Maciej, Agnieszka, Jastrzębska-Więsek, Magdalena, Vielmuth, Christin, Müller, Christa E., Kieć-Kononowicz, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531311/
https://www.ncbi.nlm.nih.gov/pubmed/37762006
http://dx.doi.org/10.3390/ijms241813707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531311/
https://www.ncbi.nlm.nih.gov/pubmed/37762006
http://dx.doi.org/10.3390/ijms241813707

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