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Hardening of Respiratory Syncytial Virus Inclusion Bodies by Cyclopamine Proceeds through Perturbation of the Interactions of the M2-1 Protein with RNA and the P Protein
Respiratory syncytial virus (RSV) RNA synthesis takes place in cytoplasmic viral factories also called inclusion bodies (IBs), which are membrane-less organelles concentrating the viral RNA polymerase complex. The assembly of IBs is driven by liquid-liquid phase separation promoted by interactions b...
Autores principales: | Diot, Cédric, Richard, Charles-Adrien, Risso-Ballester, Jennifer, Martin, Davy, Fix, Jenna, Eléouët, Jean-François, Sizun, Christina, Rameix-Welti, Marie-Anne, Galloux, Marie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531356/ https://www.ncbi.nlm.nih.gov/pubmed/37762166 http://dx.doi.org/10.3390/ijms241813862 |
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