Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia

Previous studies have shown that inhibition of TNF family member FN14 (gene: TNFRSF12A) in colon tumors decreases inflammatory cytokine expression and mitigates cancer-induced cachexia. However, the molecular mechanisms underlying the regulation of FN14 expression remain unclear. Tumor microenvironm...

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Detalles Bibliográficos
Autores principales: Ruiz, Bryan I., Lowman, Xazmin H., Yang, Ying, Fan, Qi, Wang, Tianhong, Wu, Hongmei, Hanse, Eric A., Kong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531467/
https://www.ncbi.nlm.nih.gov/pubmed/37761958
http://dx.doi.org/10.3390/genes14091818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531467/
https://www.ncbi.nlm.nih.gov/pubmed/37761958
http://dx.doi.org/10.3390/genes14091818

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