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Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia

Previous studies have shown that inhibition of TNF family member FN14 (gene: TNFRSF12A) in colon tumors decreases inflammatory cytokine expression and mitigates cancer-induced cachexia. However, the molecular mechanisms underlying the regulation of FN14 expression remain unclear. Tumor microenvironm...

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Detalles Bibliográficos
Autores principales:	Ruiz, Bryan I., Lowman, Xazmin H., Yang, Ying, Fan, Qi, Wang, Tianhong, Wu, Hongmei, Hanse, Eric A., Kong, Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531467/ https://www.ncbi.nlm.nih.gov/pubmed/37761958 http://dx.doi.org/10.3390/genes14091818

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