Exploring the Interaction of New Pyridoquinazoline Derivatives with G-Quadruplex in the c-MYC Promoter Region

Novel amino-substituted pyridoquinazolinone derivatives have been designed and synthesized as potential c-MYC G-quadruplex (G4) ligands, employing an efficient methodology. All the new compounds exhibited moderate to good antiproliferative activity against the human osteosarcoma U2OS cell line. NMR...

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Detalles Bibliográficos
Autores principales: Princiotto, Salvatore, Karelou, Maria, Ioannidi, Rachel, Beretta, Giovanni Luca, Zaffaroni, Nadia, Artali, Roberto, Kostakis, Ioannis K., Mazzini, Stefania, Dallavalle, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531603/
https://www.ncbi.nlm.nih.gov/pubmed/37762650
http://dx.doi.org/10.3390/ijms241814346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531603/
https://www.ncbi.nlm.nih.gov/pubmed/37762650
http://dx.doi.org/10.3390/ijms241814346

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