Interaction of Substrates with γ-Secretase at the Level of Individual Transmembrane Helices—A Methodological Approach

Intramembrane proteases, such as γ secretase, typically recruit multiple substrates from an excess of single-span membrane proteins. It is currently unclear to which extent substrate recognition depends on specific interactions of their transmembrane domains (TMDs) with TMDs of a protease. Here, we...

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Detalles Bibliográficos
Autores principales: Pauli, Theresa M., Julius, Ayse, Costa, Francesco, Eschrig, Sabine, Moosmüller, Judith, Fischer, Lea, Schanzenbach, Christoph, Schmidt, Fabian C., Ortner, Martin, Langosch, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531681/
https://www.ncbi.nlm.nih.gov/pubmed/37762696
http://dx.doi.org/10.3390/ijms241814396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531681/
https://www.ncbi.nlm.nih.gov/pubmed/37762696
http://dx.doi.org/10.3390/ijms241814396

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