Human γS-Crystallin Mutation F10_Y11delinsLN in the First Greek Key Pair Destabilizes and Impairs Tight Packing Causing Cortical Lamellar Cataract

Aromatic residues forming tyrosine corners within Greek key motifs are critical for the folding, stability, and order of βγ-crystallins and thus lens transparency. To delineate how a double amino acid substitution in an N-terminal-domain tyrosine corner of the CRYGS mutant p.F10_Y11delinsLN causes j...

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Detalles Bibliográficos
Autores principales: Vendra, Venkata Pulla Rao, Ostrowski, Christian, Dyba, Marzena A., Tarasov, Sergey G., Hejtmancik, J. Fielding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531703/
https://www.ncbi.nlm.nih.gov/pubmed/37762633
http://dx.doi.org/10.3390/ijms241814332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531703/
https://www.ncbi.nlm.nih.gov/pubmed/37762633
http://dx.doi.org/10.3390/ijms241814332

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