Nuclear NPM-ALK Protects Myc from Proteasomal Degradation and Contributes to Its High Expression in Cancer Stem-Like Cells in ALK-Positive Anaplastic Large Cell Lymphoma

In ALK-positive anaplastic large cell lymphoma (ALK+ALCL), a small subset of cancer stem-like (or RR) cells characterized by high Myc expression have been identified. We hypothesize that NPM-ALK contributes to their high Myc expression. While transfection of NPM-ALK into HEK293 cells effectively inc...

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Detalles Bibliográficos
Autores principales: Shang, Chuquan, Lai, Justine, Haque, Moinul, Chen, Will, Wang, Peng, Lai, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531997/
https://www.ncbi.nlm.nih.gov/pubmed/37762644
http://dx.doi.org/10.3390/ijms241814337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531997/
https://www.ncbi.nlm.nih.gov/pubmed/37762644
http://dx.doi.org/10.3390/ijms241814337

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