Arsenite Impairs BRCA1-Dependent DNA Double-Strand Break Repair, a Mechanism Potentially Contributing to Genomic Instability

BRCA1 is a key player in maintaining genomic integrity with multiple functions in DNA damage response (DDR) mechanisms. Due to its thiol-rich zinc-complexing domain, the protein may also be a potential target for redox-active and/or thiol-reactive (semi)metal compounds. The latter includes trivalent...

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Detalles Bibliográficos
Autores principales: Matthäus, Tizia, Stößer, Sandra, Seren, Hatice Yasemin, Haberland, Vivien M. M., Hartwig, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532266/
https://www.ncbi.nlm.nih.gov/pubmed/37762697
http://dx.doi.org/10.3390/ijms241814395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532266/
https://www.ncbi.nlm.nih.gov/pubmed/37762697
http://dx.doi.org/10.3390/ijms241814395

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