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Arsenite Impairs BRCA1-Dependent DNA Double-Strand Break Repair, a Mechanism Potentially Contributing to Genomic Instability

BRCA1 is a key player in maintaining genomic integrity with multiple functions in DNA damage response (DDR) mechanisms. Due to its thiol-rich zinc-complexing domain, the protein may also be a potential target for redox-active and/or thiol-reactive (semi)metal compounds. The latter includes trivalent...

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Detalles Bibliográficos
Autores principales:	Matthäus, Tizia, Stößer, Sandra, Seren, Hatice Yasemin, Haberland, Vivien M. M., Hartwig, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532266/ https://www.ncbi.nlm.nih.gov/pubmed/37762697 http://dx.doi.org/10.3390/ijms241814395

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