Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Parameters Could Predict International Society of Urological Pathology Risk Groups of Prostate Cancers on Radical Prostatectomy

Background: The International Society of Urological Pathology (ISUP) grade and positive surgical margins (PSMs) after radical prostatectomy (RP) may reflect the prognosis of prostate cancer (PCa) patients. This study aimed to investigate whether DCE-MRI parameters (i.e., K(trans), k(ep), and IAUC) c...

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Autores principales: Chang, Chun-Bi, Lin, Yu-Chun, Wong, Yon-Cheong, Lin, Shin-Nan, Lin, Chien-Yuan, Lin, Yu-Han, Sheng, Ting-Wen, Yang, Lan-Yan, Wang, Li-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532885/
https://www.ncbi.nlm.nih.gov/pubmed/37763347
http://dx.doi.org/10.3390/life13091944
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author Chang, Chun-Bi
Lin, Yu-Chun
Wong, Yon-Cheong
Lin, Shin-Nan
Lin, Chien-Yuan
Lin, Yu-Han
Sheng, Ting-Wen
Yang, Lan-Yan
Wang, Li-Jen
author_facet Chang, Chun-Bi
Lin, Yu-Chun
Wong, Yon-Cheong
Lin, Shin-Nan
Lin, Chien-Yuan
Lin, Yu-Han
Sheng, Ting-Wen
Yang, Lan-Yan
Wang, Li-Jen
author_sort Chang, Chun-Bi
collection PubMed
description Background: The International Society of Urological Pathology (ISUP) grade and positive surgical margins (PSMs) after radical prostatectomy (RP) may reflect the prognosis of prostate cancer (PCa) patients. This study aimed to investigate whether DCE-MRI parameters (i.e., K(trans), k(ep), and IAUC) could predict ISUP grade and PSMs after RP. Method: Forty-five PCa patients underwent preoperative DCE-MRI. The clinical characteristics and DCE-MRI parameters of the 45 patients were compared between the low- and high-risk (i.e., ISUP grades III-V) groups and between patients with or without PSMs after RP. Multivariate logistic regression analysis was used to identify the significant predictors of placement in the high-risk group and PSMs. Results: The DCE parameter K(trans-max) was significantly higher in the high-risk group than in the low-risk group (p = 0.028) and was also a significant predictor of placement in the high-risk group (odds ratio [OR] = 1.032, 95% confidence interval [CI] = 1.005–1.060, p = 0.021). Patients with PSMs had significantly higher prostate-specific antigen (PSA) titers, positive biopsy core percentages, K(trans-max), k(ep-median), and k(ep-max) than others (all p < 0.05). Of these, positive biopsy core percentage (OR = 1.035, 95% CI = 1.003–1.068, p = 0.032) and k(ep-ma)(x) (OR = 1.078, 95% CI = 1.012–1.148, p = 0.020) were significant predictors of PSMs. Conclusion: Preoperative DCE-MRI parameters, specifically K(trans-max) and k(ep-max), could potentially serve as preoperative imaging biomarkers for postoperative PCa prognosis based on their predictability of PCa risk group and PSM on RP, respectively.
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spelling pubmed-105328852023-09-28 Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Parameters Could Predict International Society of Urological Pathology Risk Groups of Prostate Cancers on Radical Prostatectomy Chang, Chun-Bi Lin, Yu-Chun Wong, Yon-Cheong Lin, Shin-Nan Lin, Chien-Yuan Lin, Yu-Han Sheng, Ting-Wen Yang, Lan-Yan Wang, Li-Jen Life (Basel) Article Background: The International Society of Urological Pathology (ISUP) grade and positive surgical margins (PSMs) after radical prostatectomy (RP) may reflect the prognosis of prostate cancer (PCa) patients. This study aimed to investigate whether DCE-MRI parameters (i.e., K(trans), k(ep), and IAUC) could predict ISUP grade and PSMs after RP. Method: Forty-five PCa patients underwent preoperative DCE-MRI. The clinical characteristics and DCE-MRI parameters of the 45 patients were compared between the low- and high-risk (i.e., ISUP grades III-V) groups and between patients with or without PSMs after RP. Multivariate logistic regression analysis was used to identify the significant predictors of placement in the high-risk group and PSMs. Results: The DCE parameter K(trans-max) was significantly higher in the high-risk group than in the low-risk group (p = 0.028) and was also a significant predictor of placement in the high-risk group (odds ratio [OR] = 1.032, 95% confidence interval [CI] = 1.005–1.060, p = 0.021). Patients with PSMs had significantly higher prostate-specific antigen (PSA) titers, positive biopsy core percentages, K(trans-max), k(ep-median), and k(ep-max) than others (all p < 0.05). Of these, positive biopsy core percentage (OR = 1.035, 95% CI = 1.003–1.068, p = 0.032) and k(ep-ma)(x) (OR = 1.078, 95% CI = 1.012–1.148, p = 0.020) were significant predictors of PSMs. Conclusion: Preoperative DCE-MRI parameters, specifically K(trans-max) and k(ep-max), could potentially serve as preoperative imaging biomarkers for postoperative PCa prognosis based on their predictability of PCa risk group and PSM on RP, respectively. MDPI 2023-09-21 /pmc/articles/PMC10532885/ /pubmed/37763347 http://dx.doi.org/10.3390/life13091944 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Chun-Bi
Lin, Yu-Chun
Wong, Yon-Cheong
Lin, Shin-Nan
Lin, Chien-Yuan
Lin, Yu-Han
Sheng, Ting-Wen
Yang, Lan-Yan
Wang, Li-Jen
Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Parameters Could Predict International Society of Urological Pathology Risk Groups of Prostate Cancers on Radical Prostatectomy
title Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Parameters Could Predict International Society of Urological Pathology Risk Groups of Prostate Cancers on Radical Prostatectomy
title_full Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Parameters Could Predict International Society of Urological Pathology Risk Groups of Prostate Cancers on Radical Prostatectomy
title_fullStr Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Parameters Could Predict International Society of Urological Pathology Risk Groups of Prostate Cancers on Radical Prostatectomy
title_full_unstemmed Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Parameters Could Predict International Society of Urological Pathology Risk Groups of Prostate Cancers on Radical Prostatectomy
title_short Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Parameters Could Predict International Society of Urological Pathology Risk Groups of Prostate Cancers on Radical Prostatectomy
title_sort quantitative dynamic contrast-enhanced magnetic resonance parameters could predict international society of urological pathology risk groups of prostate cancers on radical prostatectomy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532885/
https://www.ncbi.nlm.nih.gov/pubmed/37763347
http://dx.doi.org/10.3390/life13091944
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