Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes

Genome-wide association studies have identified numerous loci with allelic associations to Type 1 Diabetes (T1D) risk. Most disease-associated variants are enriched in regulatory sequences active in lymphoid cell types, suggesting that lymphocyte gene expression is altered in T1D. Here we assay gene...

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Detalles Bibliográficos
Autores principales: Newman, Jeremy R. B., Long, S. Alice, Speake, Cate, Greenbaum, Carla J., Cerosaletti, Karen, Rich, Stephen S., Onengut-Gumuscu, Suna, McIntyre, Lauren M., Buckner, Jane H., Concannon, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533491/
https://www.ncbi.nlm.nih.gov/pubmed/37758901
http://dx.doi.org/10.1038/s42003-023-05327-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533491/
https://www.ncbi.nlm.nih.gov/pubmed/37758901
http://dx.doi.org/10.1038/s42003-023-05327-7

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