Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection

Conventional bivalent antibodies against cell surface receptors often initiate unwanted signal transduction by crosslinking two antigen molecules. Biparatopic antibodies (BpAbs) bind to two different epitopes on the same antigen, thus altering crosslinking ability. In this study, we develop BpAbs ag...

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Detalles Bibliográficos
Autores principales: Akiba, Hiroki, Fujita, Junso, Ise, Tomoko, Nishiyama, Kentaro, Miyata, Tomoko, Kato, Takayuki, Namba, Keiichi, Ohno, Hiroaki, Kamada, Haruhiko, Nagata, Satoshi, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533564/
https://www.ncbi.nlm.nih.gov/pubmed/37758868
http://dx.doi.org/10.1038/s42003-023-05326-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533564/
https://www.ncbi.nlm.nih.gov/pubmed/37758868
http://dx.doi.org/10.1038/s42003-023-05326-8

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