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Extracellular Vesicle-Serpine-1 Affects Neural Progenitor Cell Mitochondrial Networks and Synaptic Density: Modulation by Amyloid Beta and HIV-1

Brain endothelial extracellular vesicles carrying amyloid beta (EV-Aβ) can be transferred to neural progenitor cells (NPCs) leading to NPC dysfunction. However, the events involved in this EV-mediated Aβ pathology are unclear. EV-proteomics studies identified Serpine-1 (plasminogen activator inhibit...

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Detalles Bibliográficos
Autores principales: András, Ibolya E., Serrano, Nelson, Djuraskovic, Irina, Fattakhov, Nikolai, Sun, Enze, Toborek, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533645/
https://www.ncbi.nlm.nih.gov/pubmed/37458985
http://dx.doi.org/10.1007/s12035-023-03456-y