Targeted inhibition of the methyltransferase SETD8 synergizes with the Wee1 inhibitor adavosertib in restraining glioblastoma growth

Despite intense research efforts, glioblastoma remains an incurable brain tumor with a dismal median survival time of 15 months. Thus, identifying new therapeutic targets is an urgent need. Here, we show that the lysine methyltransferase SETD8 is overexpressed in 50% of high-grade gliomas. The small...

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Detalles Bibliográficos
Autores principales: Della Monica, Rosa, Buonaiuto, Michela, Cuomo, Mariella, Pagano, Cristina, Trio, Federica, Costabile, Davide, de Riso, Giulia, Cicala, Francesca Sveva, Raia, Maddalena, Franca, Raduan Ahmed, Del Basso De Caro, Marialaura, Sorrentino, Domenico, Navarra, Giovanna, Coppola, Laura, Tripodi, Lorella, Pastore, Lucio, Hench, Juergen, Frank, Stephan, Schonauer, Claudio, Catapano, Giuseppe, Bifulco, Maurizio, Chiariotti, Lorenzo, Visconti, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533811/
https://www.ncbi.nlm.nih.gov/pubmed/37758718
http://dx.doi.org/10.1038/s41419-023-06167-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533811/
https://www.ncbi.nlm.nih.gov/pubmed/37758718
http://dx.doi.org/10.1038/s41419-023-06167-3

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