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Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice

Menopause is associated with cognitive deficits and brain atrophy, but the brain region and cell-specific mechanisms are not fully understood. Here, we identify a sex hormone by age interaction whereby loss of ovarian hormones in female mice at midlife, but not young age, induced hippocampal-depende...

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Detalles Bibliográficos
Autores principales: Itoh, Noriko, Itoh, Yuichiro, Meyer, Cassandra E., Suen, Timothy Takazo, Cortez-Delgado, Diego, Rivera Lomeli, Michelle, Wendin, Sophia, Somepalli, Sri Sanjana, Golden, Lisa C., MacKenzie-Graham, Allan, Voskuhl, Rhonda R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533869/
https://www.ncbi.nlm.nih.gov/pubmed/37758709
http://dx.doi.org/10.1038/s41467-023-41723-7