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p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle

Introduction: Phosphorylation of smooth muscle (SM) myosin regulatory light chain (RLC(20)) is a critical switch leading to SM contraction. The canonical view held that only the short isoform of myosin light chain kinase (MLCK1) catalyzed this reaction. It is now accepted that auxiliary kinases may...

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Detalles Bibliográficos
Autores principales: Kalra, Jaspreet, Artamonov, Mykhaylo, Wang, Hua, Franke, Aaron, Markowska, Zaneta, Jin, Li, Derewenda, Zygmunt S., Ayon, Ramon J., Somlyo, Avril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533999/
https://www.ncbi.nlm.nih.gov/pubmed/37781225
http://dx.doi.org/10.3389/fphys.2023.1228488