Interaction of ALK Inhibitors with Polyspecific Organic Cation Transporters and the Impact of Substrate-Dependent Inhibition on the Prediction of Drug–Drug Interactions

Small molecules targeting aberrant anaplastic lymphoma kinase (ALK) are active against ALK-positive non-small-cell lung cancers and neuroblastoma. Several targeted tyrosine kinase inhibitors (TKIs) have been shown to interact with polyspecific organic cation transporters (pOCTs), raising concerns ab...

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Detalles Bibliográficos
Autores principales: Tsang, Yik Pui, López Quiñones, Antonio Jesús, Vieira, Letícia Salvador, Wang, Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534724/
https://www.ncbi.nlm.nih.gov/pubmed/37765282
http://dx.doi.org/10.3390/pharmaceutics15092312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534724/
https://www.ncbi.nlm.nih.gov/pubmed/37765282
http://dx.doi.org/10.3390/pharmaceutics15092312

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