Design, Synthesis, In Silico Studies and In Vitro Evaluation of New Indole- and/or Donepezil-like Hybrids as Multitarget-Directed Agents for Alzheimer’s Disease

Alzheimer’s disease (AD) is considered a complex neurodegenerative condition which warrants the development of multitargeted drugs to tackle the key pathogenetic mechanisms of the disease. In this study, two novel series of melatonin- and donepezil-based hybrid molecules with hydrazone (3a–r) or sul...

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Detalles Bibliográficos
Autores principales: Angelova, Violina T., Georgiev, Borislav, Pencheva, Tania, Pajeva, Ilza, Rangelov, Miroslav, Todorova, Nadezhda, Zheleva-Dimitrova, Dimitrina, Kalcheva-Yovkova, Elena, Valkova, Iva V., Vassilev, Nikolay, Mihaylova, Rositsa, Stefanova, Denitsa, Petrov, Boris, Voynikov, Yulian, Tzankova, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534827/
https://www.ncbi.nlm.nih.gov/pubmed/37765003
http://dx.doi.org/10.3390/ph16091194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534827/
https://www.ncbi.nlm.nih.gov/pubmed/37765003
http://dx.doi.org/10.3390/ph16091194

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