Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice

Mutations in superoxide dismutase 1 (SOD1) that are associated with amyotrophic lateral sclerosis (ALS) cause its misfolding and aggregation. Prior studies have demonstrated that the misfolded conformation of ALS-SOD1 can template with naïve SOD1 “host proteins” to propagate, spread, and induce para...

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Detalles Bibliográficos
Autores principales: Ayers, Jacob I., Xu, Guilian, Lu, Qing, Dillon, Kristy, Fromholt, Susan, Borchelt, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534885/
https://www.ncbi.nlm.nih.gov/pubmed/37766226
http://dx.doi.org/10.3390/v15091819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534885/
https://www.ncbi.nlm.nih.gov/pubmed/37766226
http://dx.doi.org/10.3390/v15091819

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