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Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice

Mutations in superoxide dismutase 1 (SOD1) that are associated with amyotrophic lateral sclerosis (ALS) cause its misfolding and aggregation. Prior studies have demonstrated that the misfolded conformation of ALS-SOD1 can template with naïve SOD1 “host proteins” to propagate, spread, and induce para...

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Detalles Bibliográficos
Autores principales:	Ayers, Jacob I., Xu, Guilian, Lu, Qing, Dillon, Kristy, Fromholt, Susan, Borchelt, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534885/ https://www.ncbi.nlm.nih.gov/pubmed/37766226 http://dx.doi.org/10.3390/v15091819

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