Replicate Testing of Clinical Endpoints Can Prevent No-Go Decisions for Beneficial Vaccines

In vaccine efficacy trials, inaccurate counting of infection cases leads to systematic under-estimation—or “dilution”—of vaccine efficacy. In particular, if a sufficient fraction of observed cases are false positives, apparent efficacy will be greatly reduced, leading to unwarranted no-go decisions...

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Detalles Bibliográficos
Autores principales: Rosenbloom, Daniel I. S., Dudášová, Julie, Davis, Casey, Railkar, Radha A., Mehrotra, Nitin, Sachs, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535203/
https://www.ncbi.nlm.nih.gov/pubmed/37766177
http://dx.doi.org/10.3390/vaccines11091501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535203/
https://www.ncbi.nlm.nih.gov/pubmed/37766177
http://dx.doi.org/10.3390/vaccines11091501

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