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Replicate Testing of Clinical Endpoints Can Prevent No-Go Decisions for Beneficial Vaccines
In vaccine efficacy trials, inaccurate counting of infection cases leads to systematic under-estimation—or “dilution”—of vaccine efficacy. In particular, if a sufficient fraction of observed cases are false positives, apparent efficacy will be greatly reduced, leading to unwarranted no-go decisions...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535203/ https://www.ncbi.nlm.nih.gov/pubmed/37766177 http://dx.doi.org/10.3390/vaccines11091501 |