Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn’s Disease Patients through PBPK Modeling

The most common method for establishing bioequivalence (BE) is to demonstrate similarity of concentration–time profiles in the systemic circulation, as a surrogate to the site of action. However, similarity of profiles from two formulations in the systemic circulation does not imply similarity in th...

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Detalles Bibliográficos
Autores principales: Han, Chunyan, Sun, Tiancheng, Chirumamilla, Siri Kalyan, Bois, Frederic Y., Xu, Mandy, Rostami-Hodjegan, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535222/
https://www.ncbi.nlm.nih.gov/pubmed/37765205
http://dx.doi.org/10.3390/pharmaceutics15092237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535222/
https://www.ncbi.nlm.nih.gov/pubmed/37765205
http://dx.doi.org/10.3390/pharmaceutics15092237

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