Cargando…

Benzimidazole-Based Schiff Base Hybrid Scaffolds: A Promising Approach to Develop Multi-Target Drugs for Alzheimer’s Disease

A series of benzimidazole-based Schiff base derivatives (1–18) were synthesized and structurally elucidated through (1)H NMR, (13)C NMR and HREI-MS analysis. Subsequently, these synthetic derivatives were subjected to evaluation for their inhibitory capabilities against acetylcholinesterase (AChE) a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hussain, Rafaqat, Khan, Shoaib, Ullah, Hayat, Ali, Farhan, Khan, Yousaf, Sardar, Asma, Iqbal, Rashid, Ataya, Farid S., El-Sabbagh, Nasser M., Batiha, Gaber El-Saber
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535318/ https://www.ncbi.nlm.nih.gov/pubmed/37765088 http://dx.doi.org/10.3390/ph16091278

Ejemplares similares

Design, Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Study of Benzimidazole-Based Oxazole Analogues: A Promising Acetylcholinesterase and Butyrylcholinesterase Inhibitors
por: Hussain, Rafaqat, et al.
Publicado: (2023)

Investigation of novel bis-thiadiazole bearing schiff base derivatives as effective inhibitors of thymidine phosphorylase: Synthesis, in vitro bioactivity and molecular docking study
por: Hussain, Rafaqat, et al.
Publicado: (2023)

Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives
por: Hussain, Rafaqat, et al.
Publicado: (2022)

Synthesis, in vitro biological assessment, and molecular docking study of benzimidazole-based thiadiazole derivatives as dual inhibitors of α-amylase and α-glucosidase
por: Khan, Shoaib, et al.
Publicado: (2023)

Benzimidazole Schiff base derivatives: synthesis, characterization and antimicrobial activity
por: Fonkui, Thierry Youmbi, et al.
Publicado: (2019)

Melatonin as a promising therapeutic intervention for restoring ovarian function in letrozole-induced polycystic ovary syndrome rats
por: Basheer, Muddasir, et al.
Publicado: (2023)

Synthesis, In Vitro α-Glucosidase Inhibitory Activity and Molecular Docking Study of New Benzotriazole-Based Bis-Schiff Base Derivatives
por: Khan, Imran, et al.
Publicado: (2022)

Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study
por: Hussain, Rafaqat, et al.
Publicado: (2022)

Effect of sub-dermal exposure of silver nanoparticles on hepatic, renal and cardiac functions accompanying oxidative damage in male Wistar rats
por: Olugbodi, Janet Olayemi, et al.
Publicado: (2023)

Addressing cancer care inequities in sub-Saharan Africa: current challenges and proposed solutions
por: Omotoso, Olabode, et al.
Publicado: (2023)

Author Correction: Effect of sub-dermal exposure of silver nanoparticles on hepatic, renal and cardiac functions accompanying oxidative damage in male Wistar rats
por: Olugbodi, Janet Olayemi, et al.
Publicado: (2023)

Design, Synthesis, In Silico Testing, and In Vitro Evaluation of Thiazolidinone-Based Benzothiazole Derivatives as Inhibitors of α-Amylase and α-Glucosidase
por: Khan, Shoaib, et al.
Publicado: (2022)

Curative Effect of AD-MSCs against Cisplatin-Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling Pathways
por: Bekhit, Amany Abdlrehim, et al.
Publicado: (2023)

Design, Synthesis, Docking Study, and Antiproliferative Evaluation of Novel Schiff Base–Benzimidazole Hybrids with VEGFR-2 Inhibitory Activity
por: Abd El-Lateef, Hany M., et al.
Publicado: (2023)

Synthesis, DNA binding and biological evaluation of benzimidazole Schiff base ligands and their metal(ii) complexes
por: Mahmood, Khalid, et al.
Publicado: (2023)

Synthesis of New Triazole-Based Thiosemicarbazone Derivatives as Anti-Alzheimer’s Disease Candidates: Evidence-Based In Vitro Study
por: Rahim, Fazal, et al.
Publicado: (2022)

In Vitro Evaluation of the Potential Pharmacological Activity and Molecular Targets of New Benzimidazole-Based Schiff Base Metal Complexes
por: Aragón-Muriel, Alberto, et al.
Publicado: (2021)

Imidazopyridine-Based Thiazole Derivatives as Potential Antidiabetic Agents: Synthesis, In Vitro Bioactivity, and In Silico Molecular Modeling Approach
por: Hussain, Rafaqat, et al.
Publicado: (2023)

Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation
por: Beč, Anja, et al.
Publicado: (2023)

New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with in silico studies
por: Khan, Yousaf, et al.
Publicado: (2022)

Effect of Cadmium and Copper Exposure on Growth, Physio-Chemicals and Medicinal Properties of Cajanus cajan L. (Pigeon Pea)
por: Hayat, Khizar, et al.
Publicado: (2021)

Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study
por: Ullah, Hayat, et al.
Publicado: (2022)

Pyrethroid insecticides susceptibility profiles and evaluation of L1014F kdr mutant alleles in Culex quinquefasciatus from lymphatic filariasis endemic communities
por: Okafor, Martina Anurika, et al.
Publicado: (2023)

A Study of the Interaction of a New Benzimidazole Schiff Base with Synthetic and Simulated Membrane Models of Bacterial and Mammalian Membranes
por: Aragón-Muriel, Alberto, et al.
Publicado: (2021)

Thiophene-Derived Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Properties, and Molecular Docking
por: Nayab, Saira, et al.
Publicado: (2023)

Synthesis and Investigation of the Analgesic Potential of Enantiomerically Pure Schiff Bases: A Mechanistic Approach
por: Afridi, Hamid Hussain, et al.
Publicado: (2022)

Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer’s Inhibitors
por: Khan, Shoaib, et al.
Publicado: (2023)

Synthesis and Characterizations of PdNi Carbon Supported Nanomaterials: Studies of Electrocatalytic Activity for Oxygen Reduction in Alkaline Medium
por: Khan, Muhammad Sufaid, et al.
Publicado: (2021)

Docking study, molecular dynamic, synthesis, anti-α-glucosidase assessment, and ADMET prediction of new benzimidazole-Schiff base derivatives
por: Azizian, Homa, et al.
Publicado: (2022)

Molecularly Imprinted Chitosan-Based Thin Films with Selectivity for Nicotine Derivatives for Application as a Bio-Sensor and Filter
por: Ofoegbu, Obinna, et al.
Publicado: (2021)

Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors
por: Jamil, Waqas, et al.
Publicado: (2014)

New Triazinoindole Bearing Benzimidazole/Benzoxazole Hybrids Analogs as Potent Inhibitors of Urease: Synthesis, In Vitro Analysis and Molecular Docking Studies
por: Mumtaz, Sundas, et al.
Publicado: (2022)

Biological and catalytic potential of sustainable low and high valent metal-Schiff base sulfonate salicylidene pincer complexes
por: Adam, Mohamed Shaker S., et al.
Publicado: (2019)

In Vivo and In Silico Studies of Flavonoids Isolated from Pistacia integerrima as Potential Antidiarrheal Agents
por: Alhumaydhi, Fahad A., et al.
Publicado: (2021)

Synthesis of Novel Bisindolylmethane Schiff bases and Their Antibacterial Activity
por: Imran, Syahrul, et al.
Publicado: (2014)

Investigation of Novel Benzoxazole-Oxadiazole Derivatives as Effective Anti-Alzheimer’s Agents: In Vitro and In Silico Approaches
por: Anwar, Saeed, et al.
Publicado: (2023)

Deep Learning and Structure-Based Virtual Screening for Drug Discovery against NEK7: A Novel Target for the Treatment of Cancer
por: Aziz, Mubashir, et al.
Publicado: (2022)

Electrochemical, surface analysis, computational and anticorrosive studies of novel di-imine Schiff base on X65 steel surface
por: Nasser, Ahmed., et al.
Publicado: (2023)

The Benzimidazole Derivatives, B1 (N-[(1H-Benzimidazol-2-yl)Methyl]-4-Methoxyaniline) and B8 (N-{4-[(1H-Benzimidazol-2-yl)Methoxy]Phenyl}Acetamide) Attenuate Morphine-Induced Paradoxical Pain in Mice
por: Idris, Zahida, et al.
Publicado: (2019)

Ellagic acid microspheres restrict the growth of Babesia and Theileria in vitro and Babesia microti in vivo
por: Beshbishy, Amani Magdy, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8ugfo4u8a62mne50usub115ngr