Integrative analysis of multi-omics data reveals inhibition of RB1 signaling promotes apatinib resistance of hepatocellular carcinoma

Although apatinib is a promising drug for the treatment of liver cancer, the underlying drug resistance mechanism is still unclear. Here, we constructed apatinib-resistant HepG2 cells. We then characterized the epigenomic, transcriptomic, and proteomic landscapes both in apatinib-resistant and non-r...

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Detalles Bibliográficos
Autores principales: He, Ke, An, Sanqi, Liu, Fei, Chen, Ye, Xiang, Guoan, Wang, Haihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535702/
https://www.ncbi.nlm.nih.gov/pubmed/37781033
http://dx.doi.org/10.7150/ijbs.83862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535702/
https://www.ncbi.nlm.nih.gov/pubmed/37781033
http://dx.doi.org/10.7150/ijbs.83862

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