Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies

Structural-based drug design and solvent-free synthesis were combined to obtain three novel series of 5-arylethylidene-aminopyrimidine-2,4-diones (4, 5a–c, 6a,b), 5-arylethylidene-amino-2-thiopyrimidine-4-ones (7,8), and 6-arylpteridines (9,10) as dual BRD4 and PLK1 inhibitors. MTT assays of synthes...

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Detalles Bibliográficos
Autores principales: El-Kalyoubi, Samar, El-Sebaey, Samiha A., Elfeky, Sherin M., AL-Ghulikah, Hanan A., El-Zoghbi, Mona S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535864/
https://www.ncbi.nlm.nih.gov/pubmed/37765111
http://dx.doi.org/10.3390/ph16091303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535864/
https://www.ncbi.nlm.nih.gov/pubmed/37765111
http://dx.doi.org/10.3390/ph16091303

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