Pentagalloyl Glucose-Targeted Inhibition of P-Glycoprotein and Re-Sensitization of Multidrug-Resistant Leukemic Cells (K562/ADR) to Doxorubicin: In Silico and Functional Studies

Combining phytochemicals with chemotherapeutic drugs has demonstrated the potential to surmount drug resistance. In this paper, we explore the efficacy of pentagalloyl glucose (PGG) in modulating P-gp and reversing multidrug resistance (MDR) in drug-resistant leukemic cells (K562/ADR). The cytotoxic...

Descripción completa

Detalles Bibliográficos
Autores principales: Dechsupa, Nathupakorn, Khamto, Nopawit, Chawapun, Pornthip, Siriphong, Sadanon, Innuan, Phattarawadee, Suwan, Authaphinya, Luangsuep, Thitiworada, Photilimthana, Nichakorn, Maita, Witchayaporn, Thanacharttanatchaya, Rossarin, Sangthong, Padchanee, Meepowpan, Puttinan, Udomtanakunchai, Chatchanok, Kantapan, Jiraporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535865/
https://www.ncbi.nlm.nih.gov/pubmed/37765000
http://dx.doi.org/10.3390/ph16091192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535865/
https://www.ncbi.nlm.nih.gov/pubmed/37765000
http://dx.doi.org/10.3390/ph16091192

Ejemplares similares