Molecular Docking and Molecular Dynamics Studies Reveal the Anticancer Potential of Medicinal-Plant-Derived Lignans as MDM2-P53 Interaction Inhibitors

The interaction between the tumor suppressor protein p53 and its negative regulator, the MDM2 oncogenic protein, has gained significant attention in cancer drug discovery. In this study, 120 lignans reported from Ferula sinkiangensis and Justicia procumbens were assessed for docking simulations on t...

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Detalles Bibliográficos
Autores principales: Shoaib, Tagyedeen H., Abdelmoniem, Nihal, Mukhtar, Rua M., Alqhtani, Amal Th., Alalawi, Abdullah L., Alawaji, Razan, Althubyani, Mashael S., Mohamed, Shaimaa G. A., Mohamed, Gamal A., Ibrahim, Sabrin R. M., Hussein, Hazem G. A., Alzain, Abdulrahim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536213/
https://www.ncbi.nlm.nih.gov/pubmed/37764441
http://dx.doi.org/10.3390/molecules28186665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536213/
https://www.ncbi.nlm.nih.gov/pubmed/37764441
http://dx.doi.org/10.3390/molecules28186665

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