Continuous Manufacturing of Solvent-Free Cyclodextrin Inclusion Complexes for Enhanced Drug Solubility via Hot-Melt Extrusion: A Quality by Design Approach

Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot-melt extrusion (HME) for forming cyclodextrin inclusion complexes to improve the solubility and dissolution of ibupro...

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Detalles Bibliográficos
Autores principales: Munnangi, Siva Ram, Youssef, Ahmed Adel Ali, Narala, Nagarjuna, Lakkala, Preethi, Vemula, Sateesh Kumar, Alluri, Rohit, Zhang, Feng, Repka, Micheal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536280/
https://www.ncbi.nlm.nih.gov/pubmed/37765172
http://dx.doi.org/10.3390/pharmaceutics15092203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536280/
https://www.ncbi.nlm.nih.gov/pubmed/37765172
http://dx.doi.org/10.3390/pharmaceutics15092203

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