Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling

The volume of distribution at steady state (Vss) in neonates is still often estimated through isometric scaling from adult values, disregarding developmental changes beyond body weight. This study aimed to compare the accuracy of two physiologically based pharmacokinetic (PBPK) Vss prediction method...

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Detalles Bibliográficos
Autores principales: De Sutter, Pieter-Jan, Rossignol, Phebe, Breëns, Lien, Gasthuys, Elke, Vermeulen, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536587/
https://www.ncbi.nlm.nih.gov/pubmed/37765316
http://dx.doi.org/10.3390/pharmaceutics15092348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536587/
https://www.ncbi.nlm.nih.gov/pubmed/37765316
http://dx.doi.org/10.3390/pharmaceutics15092348

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