Design, Synthesis, Antitumour Evaluation, and In Silico Studies of Pyrazolo-[1,5-c]quinazolinone Derivatives Targeting Potential Cyclin-Dependent Kinases

An efficient, straightforward, and metal-free methodology to rapidly access functionalised pyrazolo-[1,5-c]quinazolinones via a [3 + 2] dipolar cycloaddition and regioselective ring expansion process was developed. The synthesised compounds were characterised by methods such as NMR, HRMS, and HPLC....

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Danyang, Yang, Chenqi, Li, Xiaogang, Liu, Dong, Wang, Yan, Wang, Xuesong, Zhang, Xueying, Tan, Yinfeng, Zhang, Yuchen, Li, Youbin, Xu, Junyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536637/
https://www.ncbi.nlm.nih.gov/pubmed/37764382
http://dx.doi.org/10.3390/molecules28186606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536637/
https://www.ncbi.nlm.nih.gov/pubmed/37764382
http://dx.doi.org/10.3390/molecules28186606

Ejemplares similares