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Design, Synthesis, Antitumour Evaluation, and In Silico Studies of Pyrazolo-[1,5-c]quinazolinone Derivatives Targeting Potential Cyclin-Dependent Kinases

An efficient, straightforward, and metal-free methodology to rapidly access functionalised pyrazolo-[1,5-c]quinazolinones via a [3 + 2] dipolar cycloaddition and regioselective ring expansion process was developed. The synthesised compounds were characterised by methods such as NMR, HRMS, and HPLC....

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Detalles Bibliográficos
Autores principales:	Zheng, Danyang, Yang, Chenqi, Li, Xiaogang, Liu, Dong, Wang, Yan, Wang, Xuesong, Zhang, Xueying, Tan, Yinfeng, Zhang, Yuchen, Li, Youbin, Xu, Junyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536637/ https://www.ncbi.nlm.nih.gov/pubmed/37764382 http://dx.doi.org/10.3390/molecules28186606

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