Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding

Tacrolimus is a crucial immunosuppressant for organ transplant patients, requiring therapeutic drug monitoring due to its variable exposure after oral intake. Physiologically based pharmacokinetic (PBPK) modelling has provided insights into tacrolimus disposition in adults but has limited applicatio...

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Detalles Bibliográficos
Autores principales: Van der Veken, Matthias, Brouwers, Joachim, Ozbey, Agustos Cetin, Umehara, Kenichi, Stillhart, Cordula, Knops, Noël, Augustijns, Patrick, Parrott, Neil John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536648/
https://www.ncbi.nlm.nih.gov/pubmed/37765200
http://dx.doi.org/10.3390/pharmaceutics15092231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536648/
https://www.ncbi.nlm.nih.gov/pubmed/37765200
http://dx.doi.org/10.3390/pharmaceutics15092231

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