Evaluating Known Zika Virus NS2B-NS3 Protease Inhibitor Scaffolds via In Silico Screening and Biochemical Assays

The NS2B-NS3 protease (NS2B-NS3pro) is regarded as an interesting molecular target for drug design, discovery, and development because of its essential role in the Zika virus (ZIKV) cycle. Although no NS2B-NS3pro inhibitors have reached clinical trials, the employment of drug-like scaffolds can faci...

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Detalles Bibliográficos
Autores principales: Santos, Lucianna H., Rocha, Rafael E. O., Dias, Diego L., Ribeiro, Beatriz M. R. M., Serafim, Mateus Sá M., Abrahão, Jônatas S., Ferreira, Rafaela S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537087/
https://www.ncbi.nlm.nih.gov/pubmed/37765127
http://dx.doi.org/10.3390/ph16091319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537087/
https://www.ncbi.nlm.nih.gov/pubmed/37765127
http://dx.doi.org/10.3390/ph16091319

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