RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS/STING/NF-κB pathway

BACKGROUND: The poor prognosis of subarachnoid hemorrhage (SAH) is often attributed to neuroinflammation. The cGAS-STING axis, a cytoplasmic pathway responsible for detecting dsDNA, plays a significant role in mediating neuroinflammation in neurological diseases. However, the effects of inhibiting c...

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Detalles Bibliográficos
Autores principales: Shao, Jiang, Meng, Yuxiao, Yuan, Kaikun, Wu, Qiaowei, Zhu, Shiyi, Li, Yuchen, Wu, Pei, Zheng, Jiaolin, Shi, Huaizhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537158/
https://www.ncbi.nlm.nih.gov/pubmed/37770901
http://dx.doi.org/10.1186/s12964-023-01274-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537158/
https://www.ncbi.nlm.nih.gov/pubmed/37770901
http://dx.doi.org/10.1186/s12964-023-01274-2

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