Cargando…

Long-Term Survival and Induction of Operational Tolerance to Murine Islet Allografts by Co-Transplanting Cyclosporine A Microparticles and CTLA4-Ig

One strategy to prevent islet rejection is to create a favorable immune-protective local environment at the transplant site. Herein, we utilize localized cyclosporine A (CsA) delivery to islet grafts via poly(lactic-co-glycolic acid) (PLGA) microparticles to attenuate allograft rejection. CsA-elutin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuppan, Purushothaman, Wong, Jordan, Kelly, Sandra, Lin, Jiaxin, Worton, Jessica, Castro, Chelsea, Paramor, Joy, Seeberger, Karen, Cuesta-Gomez, Nerea, Anderson, Colin C., Korbutt, Gregory S., Pepper, Andrew R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537425/ https://www.ncbi.nlm.nih.gov/pubmed/37765170 http://dx.doi.org/10.3390/pharmaceutics15092201

Ejemplares similares

Nanothin Conformal Coating with Poly(N-vinylpyrrolidone) and Tannic Acid (PVPON/TA) Preserves Murine and Human Pancreatic Islets Function
por: Polishevska, Kateryna, et al.
Publicado: (2023)

Bioabsorption of Subcutaneous Nanofibrous Scaffolds Influences the Engraftment and Function of Neonatal Porcine Islets
por: Kuppan, Purushothaman, et al.
Publicado: (2022)

Ferroptosis-inducing agents compromise in vitro human islet viability and function
por: Bruni, Antonio, et al.
Publicado: (2018)

Human Mesenchymal Stem Cells Protect Human Islets from Pro-Inflammatory Cytokines
por: Yeung, Telford Y., et al.
Publicado: (2012)

Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells
por: Gamble, Anissa, et al.
Publicado: (2018)

CTLA4-Ig treatment prevents murine experimental autoimmune encephalomyelitis
por: Cross, A.H., et al.
Publicado: (1994)

Effects of CTLA4-Ig on human monocytes
por: Tono, Toshihiro, et al.
Publicado: (2017)

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion
Publicado: (1993)

iPSC-MSCs and islet allograft tolerance
por: Wang, Tong-Song, et al.
Publicado: (2015)

Cooperative Roles of CTLA-4 and Regulatory T Cells in Tolerance to an Islet Cell Antigen
por: Eggena, Mark P., et al.
Publicado: (2004)

Chronic CD40L blockade is required for long-term cardiac allograft survival with a clinically relevant CTLA4-Ig dosing regimen
por: Unger, Lukas W., et al.
Publicado: (2022)

Caspase Inhibitor Therapy Synergizes With Costimulation Blockade to Promote Indefinite Islet Allograft Survival
por: Emamaullee, Juliet A., et al.
Publicado: (2010)

Cyclosporine as a preferred calcineurin inhibitor in renal allograft recipients with COVID-19 infection
por: Kemmner, Stephan, et al.
Publicado: (2020)

Single-Cell Landscape of Mouse Islet Allograft and Syngeneic Graft
por: Chen, Pengfei, et al.
Publicado: (2022)

Functional Characterization of Human T Cell Hyporesponsiveness Induced by CTLA4-Ig
por: Rochman, Yrina, et al.
Publicado: (2015)

CTLA-4Ig Improves Hyperalgesia in a Mouse Model of Osteoporosis
por: Nagao, Nobuto, et al.
Publicado: (2020)

Inhibition of Dectin-1 on Dendritic Cells Prevents Maturation and Prolongs Murine Islet Allograft Survival
por: Ren, Ao, et al.
Publicado: (2021)

Tacrolimus confers lower acute rejection rates and better renal allograft survival compared to cyclosporine
por: Kamel, Mahmoud, et al.
Publicado: (2016)

Effect of CTLA-4 gene polymorphisms on long-term kidney allograft function in Han Chinese recipients
por: Guo, Yifeng, et al.
Publicado: (2016)

Local release of rapamycin by microparticles delays islet rejection within the anterior chamber of the eye
por: Fan, Yanliang, et al.
Publicado: (2019)

HLA-B Matching Prolongs Allograft Survival in Islet Cell Transplantation
por: Lemos, Joana R. N., et al.
Publicado: (2023)

Impact of GAD65 and IA2 autoantibodies on islet allograft survival
por: Lemos, Joana R. N., et al.
Publicado: (2023)

Distinct Cyclosporin A Doses Are Required to Enhance Bone Formation Induced by Cyclic and Rest-Inserted Loading in the Senescent Skeleton
por: Srinivasan, Sundar, et al.
Publicado: (2014)

CTLA4-Ig immunosuppressive activity at the level of dendritic cell/T cell crosstalk
por: Mayer, Edda, et al.
Publicado: (2013)

Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival
por: Cheng, Pengrui, et al.
Publicado: (2023)

CTLA4Ig Improves Murine iTreg Induction via TGFβ and Suppressor Function In Vitro
por: Pilat, Nina, et al.
Publicado: (2018)

Tolerogenic vaccine composited with islet-derived multipeptides and cyclosporin A induces pTreg and prevents Type 1 diabetes in murine model
por: Zhou, Xian, et al.
Publicado: (2019)

Consecutive Low Doses of Cyclosporine A Induce Pro-Inflammatory Cytokines and Accelerate Allograft Skin Rejection
por: López-Flores, Roberto, et al.
Publicado: (2011)

Evaluation of a Collagen-Chitosan Hydrogel for Potential Use as a Pro-Angiogenic Site for Islet Transplantation
por: McBane, Joanne E., et al.
Publicado: (2013)

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28
por: Lin, Hua, et al.
Publicado: (1998)

Blood PD-1(+)TFh and CTLA-4(+)CD4(+) T cells predict remission after CTLA-4Ig treatment in early rheumatoid arthritis
por: Aldridge, Jonathan, et al.
Publicado: (2021)

A Novel Therapeutic Effect of a New Variant of CTLA4-Ig with Four Antennas That Are Terminally Capped with Sialic Acid in the CTLA4 Region
por: Piao, Yongwei, et al.
Publicado: (2022)

Pretransplant Immune Parameters Associate With Islet Allograft Outcome: Implications for Transplant Strategy?
por: Kenyon, Norma S., et al.
Publicado: (2009)

Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection
por: Vergani, Andrea, et al.
Publicado: (2013)

PD-L1 Deficiency within Islets Reduces Allograft Survival in Mice
por: Ma, Dongxia, et al.
Publicado: (2016)

FasL microgels induce immune acceptance of islet allografts in nonhuman primates
por: Lei, Ji, et al.
Publicado: (2022)

IL-2-Mediated In Vivo Expansion of Regulatory T Cells Combined with CD154–CD40 Co-Stimulation Blockade but Not CTLA-4 Ig Prolongs Allograft Survival in Naive and Sensitized Mice
por: Govender, Lerisa, et al.
Publicado: (2017)

Functional Characteristics of C-terminal Lysine to Cysteine Mutant Form of CTLA-4Ig
por: Kim, Bongi, et al.
Publicado: (2013)

Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice
por: Young, James S., et al.
Publicado: (2017)

CTLA4-Ig Effectively Controls Clinical Deterioration and Immune Condition in a Murine Model of Foxp3 Deficiency
por: Gerbaux, Margaux, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_597l3iot8gaumtds91ttgpr8m2