Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromas

Plexiform neurofibroma (PN) is a leading cause of morbidity in children with the genetic condition Neurofibromatosis Type 1 (NF1), often disfiguring or threatening vital structures. During formation of PN, a complex tumor microenvironment (TME) develops, with recruitment of neoplastic and non-neopla...

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Detalles Bibliográficos
Autores principales: Amani, Vladimir, Riemondy, Kent A., Fu, Rui, Griesinger, Andrea M., Grimaldo, Enrique, De Sousa, Graziella Ribeiro, Gilani, Ahmed, Hemenway, Molly, Foreman, Nicholas K., Donson, Andrew M., Willard, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537467/
https://www.ncbi.nlm.nih.gov/pubmed/37770931
http://dx.doi.org/10.1186/s40478-023-01639-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537467/
https://www.ncbi.nlm.nih.gov/pubmed/37770931
http://dx.doi.org/10.1186/s40478-023-01639-1

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