Development and Assessment of 1,5–Diarylpyrazole/Oxime Hybrids Targeting EGFR and JNK–2 as Antiproliferative Agents: A Comprehensive Study through Synthesis, Molecular Docking, and Evaluation

New 1,5-diarylpyrazole oxime hybrid derivatives (scaffolds A and B) were designed, synthesized, and then their purity was verified using a variety of spectroscopic methods. A panel of five cancer cell lines known to express EGFR and JNK-2, including human colorectal adenocarcinoma cell line DLD-1, h...

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Detalles Bibliográficos
Autores principales: Abdelrahman, Kamal S., Hassan, Heba A., Abdel-Aziz, Salah A., Marzouk, Adel A., Shams, Raef, Osawa, Keima, Abdel-Aziz, Mohamed, Konno, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537604/
https://www.ncbi.nlm.nih.gov/pubmed/37764297
http://dx.doi.org/10.3390/molecules28186521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537604/
https://www.ncbi.nlm.nih.gov/pubmed/37764297
http://dx.doi.org/10.3390/molecules28186521

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