Cargando…

Development and Assessment of 1,5–Diarylpyrazole/Oxime Hybrids Targeting EGFR and JNK–2 as Antiproliferative Agents: A Comprehensive Study through Synthesis, Molecular Docking, and Evaluation

New 1,5-diarylpyrazole oxime hybrid derivatives (scaffolds A and B) were designed, synthesized, and then their purity was verified using a variety of spectroscopic methods. A panel of five cancer cell lines known to express EGFR and JNK-2, including human colorectal adenocarcinoma cell line DLD-1, h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abdelrahman, Kamal S., Hassan, Heba A., Abdel-Aziz, Salah A., Marzouk, Adel A., Shams, Raef, Osawa, Keima, Abdel-Aziz, Mohamed, Konno, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537604/ https://www.ncbi.nlm.nih.gov/pubmed/37764297 http://dx.doi.org/10.3390/molecules28186521

Ejemplares similares

Synthesis of Diarylpyrazoles Containing a Phenylsulphone or Carbonitrile Moiety and their Chalcones as Possible Anti-Inflammatory Agents
por: Nassar, Ekhlass, et al.
Publicado: (2011)

Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study
por: El-Sayed, Magda A.-A., et al.
Publicado: (2017)

Novel 3,4-diarylpyrazole as prospective anti-cancerous agents
por: Pandey, Vivek, et al.
Publicado: (2020)

Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and in silico study
por: Othman, Dina I.A., et al.
Publicado: (2023)

Reaction of Nitrilimines and Nitrile Oxides with Hydrazines, Hydrazones and Oximes
por: Ferwanah, Abdel-Rahman S., et al.
Publicado: (2005)

Antimicrobial, antiproliferative activities and molecular docking of metabolites from Alternaria alternata
por: Khazaal, Heba T., et al.
Publicado: (2023)

Synthesis, DFT Calculations, Antiproliferative, Bactericidal Activity and Molecular Docking of Novel Mixed-Ligand Salen/8-Hydroxyquinoline Metal Complexes
por: Al-Farhan, Badriah Saad, et al.
Publicado: (2021)

Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study
por: Abdel-Aziz, Alaa A.-M., et al.
Publicado: (2020)

Antiproliferative, Cytotoxic, and Apoptotic Activity of Steroidal Oximes in Cervicouterine Cell Lines
por: Sánchez-Sánchez, Luis, et al.
Publicado: (2016)

Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF(V600E): Design, Synthesis, and Antiproliferative Activity
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

(Z)-1-(4-Methylphenyl)-2-(phenylsulfonyl)ethanone oxime
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling study
por: Fares, Salma, et al.
Publicado: (2021)

Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAF(V600E) Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Synthesis, Molecular Docking, and Biofilm Formation Inhibitory Activity of Bis(Indolyl)Pyridines Analogues of the Marine Alkaloid Nortopsentin
por: Abo-Salem, Heba M., et al.
Publicado: (2021)

Fluorinated and Non-Fluorinated 1,4-Diarylpyrazoles via MnO(2)-Mediated Mechanochemical Deacylative Oxidation of 5-Acylpyrazolines †
por: Utecht-Jarzyńska, Greta, et al.
Publicado: (2022)

Antiproliferative Activity and Impact on Human Gut Microbiota of New O-Alkyl Derivatives of Naringenin and Their Oximes
por: Kozłowska, Joanna, et al.
Publicado: (2023)

Synthesis, antitumour and antioxidant activities of novel α,β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study
por: El-Husseiny, Walaa M., et al.
Publicado: (2018)

New Estrone Oxime Derivatives: Synthesis, Cytotoxic Evaluation and Docking Studies
por: Canário, Catarina, et al.
Publicado: (2021)

Facile synthesis and antiproliferative activity of new 3-cyanopyridines
por: Abdel-aziz, Hassan M., et al.
Publicado: (2019)

Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity
por: Aboul-Fadl, Tarek, et al.
Publicado: (2012)

Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAF(V600E) Inhibitory Pathways
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Synthesis, Docking Study and β-Adrenoceptor Activity of Some New Oxime Ether Derivatives
por: Ghabbour, Hazem A., et al.
Publicado: (2014)

Oximes
por: Cannon, Gillian
Publicado: (2020)

The Hydrophobicity and Antifungal Potentiation of Burkholdine Analogues
por: Konno, Hiroyuki, et al.
Publicado: (2022)

Synthesis, Biological Evaluation and Molecular Docking of Certain Sulfones as Potential Nonazole Antifungal Agents
por: Fares, Mohamed, et al.
Publicado: (2016)

Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR(WT/)EGFR(T790M) inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Synthesis, in vitro antitumour activity, and molecular docking study of novel 2-substituted mercapto-3-(3,4,5-trimethoxybenzyl)-4(3H)-quinazolinone analogues
por: El-Azab, Adel S., et al.
Publicado: (2017)

Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies
por: Alkahtani, Hamad M., et al.
Publicado: (2019)

Synthesis of new thienylpicolinamidine derivatives and possible mechanisms of antiproliferative activity
por: Ismail, Mohamed A., et al.
Publicado: (2020)

Vanillin oxime inhibits lung cancer cell proliferation and activates apoptosis through JNK/ERK-CHOP pathway
por: Shen, Jie, et al.
Publicado: (2021)

EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence
por: Abdel-Aziz, Azza, et al.
Publicado: (2012)

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
por: Abdel-Aziz, Hatem A, et al.
Publicado: (2017)

Benzamide oxime
por: Xu, Shu-Qing, et al.
Publicado: (2008)

Discovery of Oxime Ethers as Hepatitis B Virus (HBV) Inhibitors by Docking, Screening and In Vitro Investigation
por: Tan, Jie, et al.
Publicado: (2018)

Eco-friendly synthesis, physicochemical studies, biological assay and molecular docking of steroidal oxime-ethers
por: Alam, Mahboob, et al.
Publicado: (2015)

Docking Studies, Synthesis, and In-vitro Evaluation of Novel Oximes Based on Nitrones as Reactivators of Inhibited Acetylcholinesterase
por: Hosseini, Seyed Ayoub, et al.
Publicado: (2017)

Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition
por: El-Husseiny, Walaa M., et al.
Publicado: (2020)

Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Gut microbiome alterations in patients with stage 4 hepatitis C
por: Aly, AbdelRahman Mahmoud, et al.
Publicado: (2016)

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives
por: Majcher, Urszula, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hs5h5jqlqfma5d8itfv4g905fn