Proline Dehydrogenase and Pyrroline 5 Carboxylate Dehydrogenase from Mycobacterium tuberculosis: Evidence for Substrate Channeling

In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and ∆(1)-pyrroline-5-carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline oxidation to glutamate via the intermediates P5C and L-glutamate-γ-semialdehyde. Both enzymes are essential for the replication of...

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Detalles Bibliográficos
Autores principales: Kumar, Santosh, Sega, Steven, Lynn-Barbe, Jamie K., Harris, Dannika L., Koehn, Jordan T., Crans, Debbie C., Crick, Dean C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537722/
https://www.ncbi.nlm.nih.gov/pubmed/37764979
http://dx.doi.org/10.3390/pathogens12091171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537722/
https://www.ncbi.nlm.nih.gov/pubmed/37764979
http://dx.doi.org/10.3390/pathogens12091171

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