Cargando…

Proline Dehydrogenase and Pyrroline 5 Carboxylate Dehydrogenase from Mycobacterium tuberculosis: Evidence for Substrate Channeling

In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and ∆(1)-pyrroline-5-carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline oxidation to glutamate via the intermediates P5C and L-glutamate-γ-semialdehyde. Both enzymes are essential for the replication of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Santosh, Sega, Steven, Lynn-Barbe, Jamie K., Harris, Dannika L., Koehn, Jordan T., Crans, Debbie C., Crick, Dean C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537722/ https://www.ncbi.nlm.nih.gov/pubmed/37764979 http://dx.doi.org/10.3390/pathogens12091171

Ejemplares similares

Appropriate Activity Assays Are Crucial for the Specific Determination of Proline Dehydrogenase and Pyrroline-5-Carboxylate Reductase Activities
por: Lebreton, Sandrine, et al.
Publicado: (2020)

Functional characterization and expression analysis of rice δ(1)-pyrroline-5-carboxylate dehydrogenase provide new insight into the regulation of proline and arginine catabolism
por: Forlani, Giuseppe, et al.
Publicado: (2015)

Synthesis and Characterization of Partially and Fully Saturated Menaquinone Derivatives
por: Koehn, Jordan T., et al.
Publicado: (2018)

Celastrol Combats Methicillin‐Resistant Staphylococcus aureus by Targeting Δ(1)‐Pyrroline‐5‐Carboxylate Dehydrogenase
por: Yuan, Zhongwei, et al.
Publicado: (2023)

Role of proline and pyrroline-5-carboxylate metabolism in plant defense against invading pathogens
por: Qamar, Aarzoo, et al.
Publicado: (2015)

Preparation of Phosphonic Acid Analogues of Proline and Proline Analogues and Their Biological Evaluation as δ(1)-Pyrroline-5-carboxylate Reductase Inhibitors
por: Qian, Renzhe, et al.
Publicado: (2018)

Structural Studies of Yeast Δ(1)-Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric State
por: Pemberton, Travis A., et al.
Publicado: (2014)

Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress
por: Cui, Bai, et al.
Publicado: (2023)

The structure of Medicago truncatula δ(1)-pyrroline-5-carboxylate reductase provides new insights into regulation of proline biosynthesis in plants
por: Ruszkowski, Milosz, et al.
Publicado: (2015)

Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy
por: Palka, Jerzy, et al.
Publicado: (2021)

Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Δ(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria
por: Watanabe, Seiya, et al.
Publicado: (2014)

Screening and characterization of proline dehydrogenase flavoenzyme producing Pseudomonas entomophila
por: Shahbaz- Mohammadi, H, et al.
Publicado: (2011)

Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis
por: Funck, Dietmar, et al.
Publicado: (2010)

Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate
por: Hancock, Chad N., et al.
Publicado: (2015)

Proline Dehydrogenase Regulates Redox State and Respiratory Metabolism in Trypanosoma cruzi
por: Paes, Lisvane Silva, et al.
Publicado: (2013)

Context of action of Proline Dehydrogenase (ProDH) in the Hypersensitive Response of Arabidopsis
por: Monteoliva, Mariela Inés, et al.
Publicado: (2014)

Erratum to: Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate
por: Hancock, Chad N., et al.
Publicado: (2016)

Computational insights on the hydride and proton transfer mechanisms of L-proline dehydrogenase
por: Yildiz, Ibrahim
Publicado: (2023)

Chemistry of Lipoquinones: Properties, Synthesis, and Membrane Location of Ubiquinones, Plastoquinones, and Menaquinones
por: Braasch-Turi, Margaret M., et al.
Publicado: (2022)

Electron Transport Lipids Fold Within Membrane-Like Interfaces
por: Braasch-Turi, Margaret M., et al.
Publicado: (2022)

NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells
por: Kazberuk, Adam, et al.
Publicado: (2022)

Can proline dehydrogenase—a key enzyme involved in proline metabolism—be a novel target for cancer therapy?
por: Xu, Xiangyuan, et al.
Publicado: (2023)

Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus
por: Huijbers, Mieke M. E., et al.
Publicado: (2018)

Proline Protects Boar Sperm against Oxidative Stress through Proline Dehydrogenase-Mediated Metabolism and the Amine Structure of Pyrrolidine
por: Feng, Chengwen, et al.
Publicado: (2020)

A Wild Allele of Pyrroline-5-Carboxylate Synthase1 Leads to Proline Accumulation in Spikes and Leaves of Barley Contributing to Improved Performance Under Reduced Water Availability
por: Frimpong, Felix, et al.
Publicado: (2021)

Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ
por: Upadhyay, Ashutosh, et al.
Publicado: (2015)

A Synthetic Isoprenoid Lipoquinone, Menaquinone-2, Adopts a Folded Conformation in Solution and at a Model Membrane Interface
por: Koehn, Jordan T., et al.
Publicado: (2017)

Decavanadate Inhibits Mycobacterial Growth More Potently Than Other Oxovanadates
por: Samart, Nuttaporn, et al.
Publicado: (2018)

Succinate Dehydrogenase is the Regulator of Respiration in Mycobacterium tuberculosis
por: Hartman, Travis, et al.
Publicado: (2014)

Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line
por: Oscilowska, Ilona, et al.
Publicado: (2022)

Proline dehydrogenase from Thermus thermophilus does not discriminate between FAD and FMN as cofactor
por: Huijbers, Mieke M. E., et al.
Publicado: (2017)

Identification of Δ-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type II
por: Merx, Jona, et al.
Publicado: (2022)

A red-shifted fluorescent substrate for aldehyde dehydrogenase
por: Minn, Il, et al.
Publicado: (2014)

Δ(1)-Pyrroline-5-Carboxylate/Glutamate Biogenesis Is Required for Fungal Virulence and Sporulation
por: Yao, Ziting, et al.
Publicado: (2013)

Functional properties and structural characterization of rice δ(1)-pyrroline-5-carboxylate reductase
por: Forlani, Giuseppe, et al.
Publicado: (2015)

Enzymology and Regulation of δ(1)-Pyrroline-5-Carboxylate Synthetase 2 From Rice
por: Sabbioni, Giuseppe, et al.
Publicado: (2021)

Generation of amine dehydrogenases with increased catalytic performance and substrate scope from ε-deaminating L-Lysine dehydrogenase
por: Tseliou, Vasilis, et al.
Publicado: (2019)

Evolution of plant δ(1)-pyrroline-5-carboxylate reductases from phylogenetic and structural perspectives
por: Forlani, Giuseppe, et al.
Publicado: (2015)

N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties
por: Scott, Gary K., et al.
Publicado: (2021)

A SNP of betaine aldehyde dehydrogenase (BADH) enhances an aroma (2-acetyl-1-pyrroline) in sponge gourd (Luffa cylindrica) and ridge gourd (Luffa acutangula)
por: Saensuk, Chatree, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_37ui3aof8fn3431pa7bgu5fj5d