Antiviral Effect of 5′-Arylchalcogeno-3-aminothymidine Derivatives in SARS-CoV-2 Infection

The understanding that zidovudine (ZDV or azidothymidine, AZT) inhibits the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 and that chalcogen atoms can increase the bioactivity and reduce the toxicity of AZT has directed our search for the discovery of novel potential anti-coronavirus compounds....

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Detalles Bibliográficos
Autores principales: Tucci, Amanda Resende, da Rosa, Raquel Mello, Rosa, Alice Santos, Augusto Chaves, Otávio, Ferreira, Vivian Neuza Santos, Oliveira, Thamara Kelcya Fonseca, Coutinho Souza, Daniel Dias, Borba, Nathalia Roberto Resende, Dornelles, Luciano, Rocha, Nayra Salazar, Mayer, João Candido Pilar, da Rocha, João B. Teixeira, Rodrigues, Oscar Endrigo D., Miranda, Milene Dias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537738/
https://www.ncbi.nlm.nih.gov/pubmed/37764472
http://dx.doi.org/10.3390/molecules28186696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537738/
https://www.ncbi.nlm.nih.gov/pubmed/37764472
http://dx.doi.org/10.3390/molecules28186696

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