Distinguishing the Concentration- vs. Bioaccumulation-Dependent Immunological and Metabolic Effects of Clofazimine

The antimycobacterial drug clofazimine (CFZ) is used as a single agent at high doses, to suppress the exaggerated inflammation associated with leprosy. Paradoxically, increasing doses of CFZ leads to bioaccumulation of CFZ in the spleen and other organs under physiologically relevant dosing regimens...

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Detalles Bibliográficos
Autores principales: Willmer, Andrew R., Diaz-Espinosa, Jennifer, Zhou, Austin, Stringer, Kathleen A., Rosania, Gus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537750/
https://www.ncbi.nlm.nih.gov/pubmed/37765318
http://dx.doi.org/10.3390/pharmaceutics15092350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537750/
https://www.ncbi.nlm.nih.gov/pubmed/37765318
http://dx.doi.org/10.3390/pharmaceutics15092350

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