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Distinguishing the Concentration- vs. Bioaccumulation-Dependent Immunological and Metabolic Effects of Clofazimine
The antimycobacterial drug clofazimine (CFZ) is used as a single agent at high doses, to suppress the exaggerated inflammation associated with leprosy. Paradoxically, increasing doses of CFZ leads to bioaccumulation of CFZ in the spleen and other organs under physiologically relevant dosing regimens...
Autores principales: | Willmer, Andrew R., Diaz-Espinosa, Jennifer, Zhou, Austin, Stringer, Kathleen A., Rosania, Gus R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537750/ https://www.ncbi.nlm.nih.gov/pubmed/37765318 http://dx.doi.org/10.3390/pharmaceutics15092350 |
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