QS21-Initiated Fusion of Liposomal Small Unilamellar Vesicles to Form ALFQ Results in Concentration of Most of the Monophosphoryl Lipid A, QS21, and Cholesterol in Giant Unilamellar Vesicles

Army Liposome Formulation with QS21 (ALFQ), a vaccine adjuvant preparation, comprises liposomes containing saturated phospholipids, with 55 mol% cholesterol relative to the phospholipids, and two adjuvants, monophosphoryl lipid A (MPLA) and QS21 saponin. A unique feature of ALFQ is the formation of...

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Detalles Bibliográficos
Autores principales: Abucayon, Erwin G., Rao, Mangala, Matyas, Gary R., Alving, Carl R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537867/
https://www.ncbi.nlm.nih.gov/pubmed/37765181
http://dx.doi.org/10.3390/pharmaceutics15092212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537867/
https://www.ncbi.nlm.nih.gov/pubmed/37765181
http://dx.doi.org/10.3390/pharmaceutics15092212

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