MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC

BACKGROUND: Although the clinical application of PARP inhibitors has brought hope to ovarian cancer, the problem of its resistance has become increasingly prominent. Therefore, clinical experts have been focused on finding specific indicators and therapeutic targets that can be used for resistance m...

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Detalles Bibliográficos
Autores principales: Zhuang, Xucui, Xiao, Rourou, Fu, Yu, Yang, Bin, Fan, Junpeng, Lu, Funian, Qin, Tianyu, Yang, Xiaohang, Hu, Xingyuan, Yin, Jingjing, Li, Wenting, Kang, Xiaoyan, Chen, Gang, Hu, Dianxing, Sun, Chaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537967/
https://www.ncbi.nlm.nih.gov/pubmed/37759323
http://dx.doi.org/10.1186/s13578-023-01117-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537967/
https://www.ncbi.nlm.nih.gov/pubmed/37759323
http://dx.doi.org/10.1186/s13578-023-01117-0

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