Study of the mass balance, biotransformation and safety of [(14)C]SHR8554, a novel μ-opioid receptor injection, in healthy Chinese subjects

Background: SHR8554 is a novel μ-opioid receptor-biased agonist. It has analgesic effects by selectively activating the G protein-coupled pathway. Additionally, it can weakly activate the ß-arrestin-2 pathway, resulting in a limited number of side effects, such as gastrointestinal inhibition. Previo...

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Detalles Bibliográficos
Autores principales: Shi, Rupeng, Chai, Yi, Feng, Hao, Xie, Lijun, Zhang, Lulu, Zhong, Tianqi, Chen, Juan, Yan, Peng, Zhu, Bei, Zhao, Jun, Zhou, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538116/
https://www.ncbi.nlm.nih.gov/pubmed/37781692
http://dx.doi.org/10.3389/fphar.2023.1231102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538116/
https://www.ncbi.nlm.nih.gov/pubmed/37781692
http://dx.doi.org/10.3389/fphar.2023.1231102

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