Cargando…
Study of the mass balance, biotransformation and safety of [(14)C]SHR8554, a novel μ-opioid receptor injection, in healthy Chinese subjects
Background: SHR8554 is a novel μ-opioid receptor-biased agonist. It has analgesic effects by selectively activating the G protein-coupled pathway. Additionally, it can weakly activate the ß-arrestin-2 pathway, resulting in a limited number of side effects, such as gastrointestinal inhibition. Previo...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538116/ https://www.ncbi.nlm.nih.gov/pubmed/37781692 http://dx.doi.org/10.3389/fphar.2023.1231102 |