Fragment merging approach for design, synthesis, and biological assessment of urea/acetyl hydrazide clubbed thienopyrimidine derivatives as GSK-3β inhibitors

New thienopyrimidine derivatives were designed and synthesized as GSK-3β inhibitors based on the structure of active binding site of GSK-3β enzyme. In this study, compounds 6b and 6a were found to be moderate GSK-3β inhibitors with IC(50s) 10.2 and 17.3 μM, respectively. Molecular docking study was...

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Detalles Bibliográficos
Autores principales: Saleh, Joseph S., Abd El Hadi, Soha R., Ibrahim, Hany S., Elrazaz, Eman Z., Abouzid, Khaled A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538245/
https://www.ncbi.nlm.nih.gov/pubmed/37759329
http://dx.doi.org/10.1186/s13065-023-01026-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538245/
https://www.ncbi.nlm.nih.gov/pubmed/37759329
http://dx.doi.org/10.1186/s13065-023-01026-w

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